反应详情

98 g (0.23 mole) 5-(4-[2-(4-methanesulfonyloxyphenyl)ethoxy]benzylidene)thiazolidine-2,4-dione and 89 g (0.35 mole) diethyl-1,4-dihydro-2,6-dimethyl-3,5-pyridine dicarboxylate was heated under reduced pressure until it melted (160° C.). The reaction mixture was allowed to stay at this temperature for 5 hours. The reaction mixture was then taken off the heat and toluene was added when the temperature was below 100° C. The crystals were collected and washed with diethyl ether and recrystallized in toluene to give 77 g (yield 79%) of the desired product.

1. custom(160° C.)
2. temperatureheat
3. customwas below 100° C
4. customThe crystals were collected
5. washwashed with diethyl ether
6. customrecrystallized in toluene