5-(4-[2-(4-Tert-butyloxycarbonylaminophenyl)ethoxy]benzylidene)thiazolidine-2,4-dione → 5-(-[4-[2-(4-Tert-butyloxycarbonylaminophenyl)ethoxy]phenyl]methyl)thiazolidine-2,4-dione

HRID 1595502노트

반응식

HRID 1595502 반응식
[C:1]([O:5][C:6]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][O:17][C:18]2[CH:31]=[CH:30][C:21]([CH:22]=[C:23]3[S:27][C:26](=[O:28])[NH:25][C:24]3=[O:29])=[CH:20][CH:19]=2)=[CH:11][CH:10]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[H][H]>C(OCC)(=O)C.[Pd]>[C:1]([O:5][C:6]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][O:17][C:18]2[CH:31]=[CH:30][C:21]([CH2:22][CH:23]3[S:27][C:26](=[O:28])[NH:25][C:24]3=[O:29])=[CH:20][CH:19]=2)=[CH:11][CH:10]=1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

참가 물질

5

반응물 2

HCID 541005505-(4-[2-(4-Tert-butyloxycarbonylaminophenyl)ethoxy]benzylidene)thiazolidine-2,4-dioneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 98895665-(-[4-[2-(4-Tert-butyloxycarbonylaminophenyl)ethoxy]phenyl]methyl)thiazolidine-2,4-dione수율 99.1%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

A solution of 0.5 g (1.14 mmole) 5-(4-[2-(4-tert-butyloxycarbonylaminophenyl)ethoxy]benzylidene)thiazolidine-2,4-dione in ethyl acetate was hydrogenated in the presence of 5% palladium on charcoal at room temperature and atmospheric pressure until hydrogen uptake ceased. The solution was filtered through celite, the filter pad was washed with ethyl acetate and the filtrate was evaporated to give 0.5 g (yield 99%) of 5-(-[4-[2-(4-tert-butyloxycarbonylaminophenyl)ethoxy]phenyl]methyl)thiazolidine-2,4-dione.

후처리

  1. filtrationThe solution was filtered through celite
  2. washthe filter pad was washed with ethyl acetate
  3. customthe filtrate was evaporated

출처 및 근거

ORD 기록
ord-d62f5c846e2a404ebb9acfc1910157cc
출처 데이터셋
uspto-grants-2001_09
특허 번호
US06288096B1

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