Acetic Acid → HCID 54551481, compound

Participants

Reaction Steps

0.25 g (2.9 mmole) piperidine, 0.174 g (2.9 mmole) acetic acid, 120 ml toluene, 2.5 g (5.8 mmole) 4-[2-(4-formylphenoxy)ethyl]phenyl 3-nitrobenzenesulfonate and 0.86 g (7.3 mmole) 2,4-thiazolidinedione were refluxed with water separation in a Dean-Stark apparatus. When the reaction mixture was allowed to cool yellow crystals formed. The crystals were collected by filtration and stirred in methanol. Filtration gave 2 g (yield 65.5%) of 5-(4-[2-(4-(3-nitrophenylsulfonyloxy)phenyl)ethoxy]benzylidene)thiazolidine-2,4-dione.

Provenance & Evidence