Thiazolidinedione → HCID 53906345, compound

Participants

Reaction Steps

1.7 g (5.3 mmole) 2-[2-(4-formylphenoxy)ethyl]phenyl methanesulfonate, 0.77 g (6.6 mmole) 2,4-thiazolidinedione and 1.06 g (13.2 mmole) sodium acetate were heated to 130° C. and allowed to stay at 130° C. for 10 minutes. The reaction mixture was taken off the heat and water:acetone (2:1) was added, the formed solid material was stirred with water and acetic acid, the precipitate was collected by filtration and washed with diethyl ether and recrystallized in dichloromethane to give 1.63 g (yield 61%) of 5-(4-[2-(2-methanesulfonyloxyphenyl)ethoxy]benzylidene)thiazolidine-2,4-dione.

Provenance & Evidence