Hantzsch ester → HCID 21705023, compound

Participants

Reaction Conditions

Reaction Steps

1.63 g (3.2 mmole) 5-(4-[2-(2 methanesulfonyloxyphenyl)ethoxy]benzylidene)thiazolidine-2,4-dione and 1.23 g (4.8 mmole) diethyl-1,4-dihydro-2,6-dimethyl-3,5-pyridine dicarboxylate was mixed and heated to 150° C. and kept at this temperature for 1 hour. The reaction mixture was cooled and purified by chromatography on silica gel using ethyl acetate:petroleum ether (1:2) as eluent to give 0.684 g (yield 51%) of the desired product.

Provenance & Evidence