Triethylamine → HCID 21704949, compound

Participants

Reaction Steps

47 g (0.412 mole) methanesulfonyl chloride in dichloromethane was added in small portions to a solution of 20 g (0.103 mole) N-[4-(2-hydroxyethyl)phenyl]-N1-methylurea and 41.7 g (0.412 mole) triethylamine in 500 ml dichloromethane at 0° C. After stirring at room temperature over night the reaction mixture was washed with 2 M hydrochloric acid and sodium bicarbonate. The organic phase was dried and concentrated by evaporation in vacuo and the formed precipitate was collected by filtration to give 8.81 g (yield 31%) of 4-(methylaminocarbonylamino)phenethyl methanesulfonate.

Provenance & Evidence