HCID 54012500, compound → HCID 21704995, compound

Participants

Reaction Steps

1 g (2.5 mmole) 5-(4-[2-(4-methoxycarbonylaminophenyl)ethoxy]benzylidene)thiazolidine-2,4-dione was mixed with Pd/C (5%) and hydrogenated in ethyl acetate for 4 hours at room temperature. The catalyst was filtered off through celite and the solvent was evaporated in vacuo. All of the starting material was not consumed so the hydrogenation was restarted as above. The catalyst was filtered off through celite and the solvent was evaporated in vacuo. The crude product was purified by crystallization in diethyl ether to give 0.47 g (yield 47%) of the desired product.

Provenance & Evidence