HCID 54228087, compound → HCID 21705004, compound

Participants

Reaction Steps

1.5 g (3.1 mmole) 5-(4-[2-(4-(benzenesulfonyloxy)phenyl)ethoxy]benzylidene)thiazolidine-2,4-dione was hydrogenated on 1 g Pd/C (5%) in ethyl acetate and acetic acid (2.5%) at atmospheric pressure for 24 hours. The reaction mixture was filtered through celite and the solvent was evaporated in vacuo. The starting material was not completely consumed, therefore the hydrogenation was restarted twice with Pd/C (10%), followed by purification by chromatography on silica gel using dichloromethane:methanol (95:5) as eluent to give 0.728 g (yield 48.6%) of the desired product.

Provenance & Evidence