4-Hydroxybenzaldehyde → HCID 21704994, compound

Participants

Reaction Steps

50 g (0.154 mole) 3-methoxy-4-(methylsulfonyloxy)phenethyl methanesulfonate, 48.8 g 0.4 mole) p-hydroxybenzaldehyde, 65.45 g 0.473 mole) potassium carbonate in 500 ml acetonitrile was refluxed for 4 hours. The precipitate was filtered off and the solvent was evaporated. Dichloromethane was added and the organic phase was washed with water, dried (magnesium sulfate), filtered and the solvent was evaporated to give 34 g (yield 63%) of 4-[2-(4-formylphenoxy)ethyl]-2-methoxyphenyl methanesulfonate.

Provenance & Evidence