Acetic Acid → HCID 54051251, compound

Participants

Reaction Steps

34 g (97 mmole) 4-[2-(4-formylphenoxy)ethyl]-2-methoxyphenyl methanesulfonate, 12.5 g (107 mmole) 2,4-thiazolidinedione, 0.5 ml piperidine and 0.5 ml acetic acid in 500 ml toluene was refluxed with water separation in a Dean-Stark apparatus for 4 hours. The solvent was evaporated, acetic acid was added and the mixture was heated. The formed precipitate was filtered and washed with diethyl ether to give 31.5 g (yield 72%) of 5-(4-[2-(3-methoxy-4-methanesulfonyloxyphenyl)ethoxy]benzylidene)thiazolidine-2,4-dione.

Provenance & Evidence