Acetic Acid → HCID 54069217, compound

Participants

Reaction Steps

5.31 g (16.6 mmole) 3-[2-(4-formylphenoxy)ethyl]phenyl methanesulfonate, 2.13 g (18.2 mmole) 2,4-thiazolidinedione, 0.5 ml piperidine and 0.5 ml acetic acid in 300 ml toluene were refluxed with water separation in a Dean-Stark apparatus for 4 hours. The solvent was evaporated, acetic acid was added and the mixture was heated. The formed precipitate was filtered off and washed with diethyl ether to give 3.6 g (yield 51%) of 5-(4-[2-(3-methanesulfonyloxyphenyl)ethoxy]benzylidene)thiazolidine-2,4-dione.

Provenance & Evidence