Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hantzsch ester | HCID 70849 | — |
| Reactant | HCID 53634277 | HCID 53634277 | — |
| Product | HCID 21705021 | HCID 21705021 | 38.3% |
Reaction Steps
2 g (4.22 mmole) 5-(4-[2-(4-trifluoromethanesulfonyloxyphenyl)ethoxy]benzylidene)thiazolidine-2,4-dione and 2.14 g (8.44 mmole) diethyl-1,4-dihydro-2,6-dimethyl-3.5-pyridine dicarboxylate were mixed and heated to 180° C. under vacuum when it melted, the temperature raised to 230° C. and after 30 minutes the heat was removed. Purification by chromatography on silica gel with heptane/ethyl acetate as eluent gave 0.768 g (yield 38%) of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06288096B1 |
|---|
| Source dataset | uspto-grants-2001_09 |
|---|
| ORD ID | ord-9f5da8fc9faa49c79419517d148f93e1 |
|---|
| Source note | uspto-grants-2001_09 |
|---|
