Acetyl chloride → 1,1'-[Chloro(phenyl)methylene]bis(4-fluorobenzene)

HRID 1595553Notes

Reaction equation

HRID 1595553 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)O)=[CH:4][CH:3]=1.C([Cl:26])(=O)C>ClCCl>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[Cl:26])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 12580270Bis(4-fluorophenyl)(phenyl)methanol

Product 1

HCID 145798251,1'-[Chloro(phenyl)methylene]bis(4-fluorobenzene)

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Bis(4-fluorophenyl)phenylmethanol (0.092 mol) was added to a 20% solution of acetyl chloride in dichloromethane (50 mL) at rt. The resulting purple solution was stirred for 12 h after which the solvent was removed by evaporation. Toluene (100 mL) was added to the residue and then evaporated, affording crude bis(4-fluorophenyl)phenylchloromethane which was used without purification in the following step.

Workup

  1. customwas removed by evaporation
  2. additionToluene (100 mL) was added to the residue
  3. customevaporated

Sources & evidence

ORD record
ord-bb14b32296b34c8a8ba0d2af66b83a12
Source dataset
uspto-grants-2001_09
Patent number
US06288122B1

Reaction notes

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