Acetyl chloride → HCID 21705154, compound

HRID 1595556Notes

Reaction equation

HRID 1595556 reaction equation
C([Cl:4])(=O)C.[F:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([C:21]2[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=2)([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[F:20])O)=[CH:8][CH:7]=1>ClCCl>[F:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([C:21]2[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=2)([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[F:20])[Cl:4])=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 21705161HCID 21705161, compound

Product 1

HCID 21705154HCID 21705154, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A 20% solution of acetyl chloride in dichloromethane (60 mL) was added to the crude bis(4-fluorophenyl)-2-fluorophenylmethanol at rt. The resulting solution was stirred for 12 h after which the solvent was removed by evaporation. Toluene (100 mL) was added to the residue and was then evaporated to afford crude bis(4-fluorophenyl)-2-fluorophenylchloromethane which was used without purification in the next step.

Workup

  1. customwas removed by evaporation
  2. additionToluene (100 mL) was added to the residue
  3. customwas then evaporated

Sources & evidence

ORD record
ord-fbd97c5246c344ea97ffb56938ede13c
Source dataset
uspto-grants-2001_09
Patent number
US06288122B1

Reaction notes

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