Acetyl chloride → HCID 21705165, compound

HRID 1595557Notes

Reaction equation

HRID 1595557 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=2)([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[CH:11]=2)O)=[CH:4][CH:3]=1.C([Cl:27])(=O)C>ClCCl>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=2)([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[CH:11]=2)[Cl:27])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 2760802HCID 2760802, compound

Product 1

HCID 21705165HCID 21705165, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Bis(4-fluorophenyl)-3-fluorophenylmethanol (999 mg, 3.18 mmol) was added to a 20% solution of acetyl chloride in dichloromethane (10 mL) at rt. The resulting purple solution was stirred for 12 h after which the solvent was removed by evaporation. Toluene (20 mL) was added to the residue and then evaporated affording crude bis(4-fluorophenyl)-3-fluorophenylchloromethane which was used in the next step without purification.

Workup

  1. customwas removed by evaporation
  2. additionToluene (20 mL) was added to the residue
  3. customevaporated

Sources & evidence

ORD record
ord-4d866c6d7e434d3ab19b94707bd4ef51
Source dataset
uspto-grants-2001_09
Patent number
US06288122B1

Reaction notes

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