2-(4-Methoxy-benzenesulfonyl)-3-phenyl-propionic acid ethyl ester → 2-(4-Methoxy-benzenesulfonyl)3-phenyl-propionic acid

HRID 1595567Notes

Reaction equation

HRID 1595567 reaction equation
C([O:3][C:4](=[O:24])[CH:5]([S:13]([C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=1)(=[O:15])=[O:14])[CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)C>CO.[OH-].[Na+]>[CH3:23][O:22][C:19]1[CH:18]=[CH:17][C:16]([S:13]([CH:5]([CH2:6][C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:4]([OH:24])=[O:3])(=[O:15])=[O:14])=[CH:21][CH:20]=1

Participants

4

Reactant 1

HCID 108934292-(4-Methoxy-benzenesulfonyl)-3-phenyl-propionic acid ethyl ester

Product 1

HCID 108709182-(4-Methoxy-benzenesulfonyl)3-phenyl-propionic acid

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

To a stirred solution of 2-(4-methoxy-benzenesulfonyl)-3-phenyl-propionic acid ethyl ester (348 mg, 1 mmol) in methanol (25 ml), 10 N NaOH (10 ml) was added. The reaction mixture was stirred at room temperature for 48 hours. At the end, the reaction mixture was concentrated and carefully neutralized with dilute HCl. The residue obtained was extracted with chloroform, washed well with water, dried and concentrated. The product obtained was purified by silica-gel column chromatography by eluting with ethyl acetate: methanol (95:5) to afford 2-(4-methoxy-benzenesulfonyl)3-phenyl-propionic acid as a colorless oil.

Workup

  1. concentrationAt the end, the reaction mixture was concentrated
  2. customThe residue obtained
  3. extractionwas extracted with chloroform
  4. washwashed well with water
  5. customdried
  6. concentrationconcentrated
  7. customThe product obtained
  8. customwas purified by silica-gel column chromatography
  9. washby eluting with ethyl acetate: methanol (95:5)

Sources & evidence

ORD record
ord-a5a41c32bd064d26b91be99e83cce1d7
Source dataset
uspto-grants-2001_09
Patent number
US06288086B1

Reaction notes

Loading…