4-Methoxybenzenethiol → 2-(4-Methoxy-phenylsulfanyl)-octanoic acid ethyl ester

HRID 1595579Notes

Reaction equation

HRID 1595579 reaction equation
[CH2:1]([O:3][C:4](=[O:13])[CH:5](Br)[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11])[CH3:2].[CH3:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([SH:22])=[CH:18][CH:17]=1>>[CH2:1]([O:3][C:4](=[O:13])[CH:5]([S:22][C:19]1[CH:20]=[CH:21][C:16]([O:15][CH3:14])=[CH:17][CH:18]=1)[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11])[CH3:2]

Participants

3

Reactant 2

HCID 127654-MethoxybenzenethiolHCID 95580Ethyl 2-bromooctanoate

Product 1

HCID 114383212-(4-Methoxy-phenylsulfanyl)-octanoic acid ethyl ester

Procedure

2-(4-Methoxy-phenylsulfanyl)-octanoic acid ethyl ester was prepared according to the general method as outlined in example 9. Starting from ethyl-2-bromooctanoate (11.8 g, 473 mmol) and 4-methoxythiophenol (6 g, 43 mmol). Yield: 7.24 g (57%); clear oil; MS: 311.2 (M+H)+.

Sources & evidence

ORD record
ord-69b2f9b740cb4987a487f1be1ce55fa7
Source dataset
uspto-grants-2001_09
Patent number
US06288086B1

Reaction notes

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