4-Methoxybenzenethiol → 2-(4-Methoxy-phenylsulfanyl)heptanoic acid ethyl ester

HRID 1595612Notes

Reaction equation

[CH2:1]([O:3][C:4](=[O:12])[CH:5](Br)[CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])[CH3:2].[CH3:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([SH:21])=[CH:17][CH:16]=1>>[CH2:1]([O:3][C:4](=[O:12])[CH:5]([S:21][C:18]1[CH:19]=[CH:20][C:15]([O:14][CH3:13])=[CH:16][CH:17]=1)[CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])[CH3:2]

Participants

Reactant 2

HCID 127654-Methoxybenzenethiol

HCID 95333Ethyl 2-bromoheptanoate

Product 1

HCID 543572462-(4-Methoxy-phenylsulfanyl)heptanoic acid ethyl esterYield 108.8%

Procedure

2-(4-Methoxy-phenylsulfanyl)-heptanoic acid ethyl ester (13.8 g, 98%) was prepared according to the general method as outlined in example 1 starting from ethyl-2-bromoheptanoate (11 g, 47 mmol) and 4-methoxythiophenol (6 g, 42.8 mmol), as a yellow oil; MS: 297.2 (M+H)+.

Sources & evidence

ORD record: ord-bfca0cb42291470da349c7c80a890b6e
Source dataset: uspto-grants-2001_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06288086B1

Reaction notes

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