HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1595711Generated: October 25, 2026
Dimethylformamide dimethyl acetal → (E)-methyl 4-(benzyloxy)-2-((dimethylamino)methyleneamino)-5-methoxybenzoate
https://huagongshe.com/reaction/1595711
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Reactant | Methyl 2-amino-4-(benzyloxy)-5-methoxybenzoate | HCID 11098159 | — |
| Product | (E)-methyl 4-(benzyloxy)-2-((dimethylamino)methyleneamino)-5-methoxybenzoate | HCID 21697307 | — |
Reaction Steps
A stirred mixture of 70.0 g (244 mmol) of methyl 2-amino-4-benzyloxy-5-methoxybenzoate (Phytochemistry 1976, 15, 1095) and 52 ml of dimethylformamide dimethyl acetal was heated at 100° C. for 1.5 h, cooled, and evaporated directly under high vacuum to give 81.3 g of off-white solid, mp 134-140° C.; NMR (CDCl3) d 3.01 (s, Me2N).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06288082B1 |
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| Source dataset | uspto-grants-2001_09 |
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| ORD ID | ord-9baa2773121e43ec91d4eb61da03e682 |
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| Source note | uspto-grants-2001_09 |
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