Dimethylformamide dimethyl acetal → Methyl 4-ethoxy-5-methoxy-2-(dimethylaminomethyleneamino)benzoate

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

A mixture of 15.056 g ( 66.9 mmol) methyl 2-amino-4-ethoxy-5-methoxybenzoate and 14.1 ml (100 mmol) N,N-dimethylformamide dimethylacetal was heated to 100° C. under N2. At 4.5 hours added 4.7 ml (33.3 mmol) more DMF/DMA and removed heat at 5 hours. Stripped solvent, azeotroped with toluene, and dried in vacuo, giving 18.211 g of grey-brown solid: mass spectrum (electrospray m/e): M+H=281.3.

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