HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodoethane → Methyl 4-ethoxy-3-methoxybenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodoethane | HCID 6340 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl Vanillate | HCID 19844 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Methyl 4-ethoxy-3-methoxybenzoate | HCID 592192 | 89.8% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
A mixture of 25.0 g (137 mmol) methyl vanillate, 38.87 g (274 mmol) potassium carbonate, 500 ml DMF, and 16.5 ml (206 mmol) ethyl iodide was heated to 100° C. under N2. At 2.5 hours, cooled and removed solids. Stripped solvent, and partitioned between water and methylene chloride. Stripped solvent and dried in vacuo, giving 25.85 g of white solid: mass spectrum (EI m/e): M=210.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06288082B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-0e91e7a1b20b4b6a9c5ae124bdea20a5 |
| Source note | uspto-grants-2001_09 |