反应详情

To 5 ml of trifluoroacetic acid was added 206 mg 7-benzyloxy-4-(2,3-dihydro-1H-indol-6-ylamino)-6-methoxy-quinoline-3-carbonitrile and the reaction was refluxed for 1.5 h. The TFA was removed under vacuum and the resulting film was dissolved in 7 ml of methanol followed by the addition of 50 ml of ice cold saturated sodium bicarbonate. The solution was allowed to stand at 10° C. for 1 h. The resulting solid was isolated, washed with excess water and dried under vacuum at 80° C. to yield 107 mg of 4-(2,3-dihydro-1H-indol-6-ylamino)-7-hydroxy-6-methoxy-quinoline-3-carbonitrile. This compound was taken directly on to the next step without purification.

1. temperaturethe reaction was refluxed for 1.5 h
2. customThe TFA was removed under vacuum
3. dissolutionthe resulting film was dissolved in 7 ml of methanol
4. additionfollowed by the addition of 50 ml of ice cold saturated sodium bicarbonate
5. customThe resulting solid was isolated
6. washwashed with excess water
7. customdried under vacuum at 80° C.