1H-Indazol-6-amine → HCID 9841012, compound

Participants

Reaction Steps

A mixture of 1.00 g (4.07 mmol) of 9-chloro-2,3-dihydro[1,4]dioxino[2,3-g]quinoline-8-carbonitrile and 0.649 g (4.88 mmol) of 6-aminoindazole in 25 mL of EtOH was refluxed under N2 for 5.7 h. Satd NaHCO3 was added and the solvent was removed. The residue was slurried with H2O, filtered, washed with H2O and cold EtOH and dried. The crude product was boiled with EtOH, filtered and dried in vacuo (50° C.) to yield 1.06 g of 9-(1H-indazol-6-ylamino)-2,3-dihydro[1,4]dioxino[2,3-g]quinoline-8-carbonitrile as tan crystals: mass spectrum (electrospray, m/e): M+H 344.3.

Provenance & Evidence