6-Aminoquinoline → HCID 9924833, compound

Participants

Reaction Steps

Using an analogous procedure to that described in Example 150, 248.7 mg (1 mmol) of 4-chloro-6,7-dimethoxy-3-quinolinecarbonitrile, 173.8 mg (1.2 mmol) of 6-aminoquinoline and 115.6 mg (1 mmol) of pyridine hydrochloride in 15 mL of 2-ethoxyethanol was refluxed for 6 hr. The work up gave 212.5 mg (59.5%) of the product as a orange solid, m.p. 241-243° C., mass (electrospray, m/e): M+H 356.8. HRCIMS: calcd 356.127 for C20H17N5O2 (M+), obsd 356.1275.

Provenance & Evidence