Glycol monoethyl ether → HCID 178486709, compound

Participants

Reaction Steps

Using an analogous procedure to that described in Example 150, 278.7 mg (1 mmol) of 4-chloro-6,7-dimethoxy-3-quinolinecarbonitrile, 161.3 mg (1.2 mmol) of 5-aminobenzotriazole and 115.6 mg (1 mmol) of pyridine hydrochloride in 10 mL of 2-ethoxyethanol was refluxed for 10 min. The work up gave 246.3 mg (65.4%) of the product as a yellow solid, m.p. 205° C. (dec.), mass (electrospray, m/e): M+H 376.9. HRCIMS: calcd 376.128 for C19H16N6O3(M+), obsd 376.1264.

Provenance & Evidence