Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Thiomorpholine | HCID 67164 | — |
| Reactant | 7-(2-Chloroethoxy)-4-(1H-indazol-6-ylamino)-6-methoxyquinoline-3-carbonitrile | HCID 10294003 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | HCID 10115505 | HCID 10115505 | — |
Reaction Steps
Using an analogous procedure to that described in Example 157, 173.0 mg (0.44 mmol) of the 7-(2-chloro-ethoxy)-4-(1H-indazol-6-ylamino)-6-methoxy-quinoline-3-carbonitrile, 454.0 mg (4.4 mmol) of thiomopholine and 66.0 mg (0.44 mmol) of sodium iodide in 4 mL of DME was heated at 135° C. for 16 hr. The work up gave 108.4 mg (53.5%) of the product as a light yellow solid, m.p. 213-215° C., mass (electrospray, m/e): M+H 461.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06288082B1 |
|---|
| Source dataset | uspto-grants-2001_09 |
|---|
| ORD ID | ord-4ed967d35adc4b758a88f2671eabed5d |
|---|
| Source note | uspto-grants-2001_09 |
|---|
