Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | 1,3-Dioxolane-2-methanamine, N-methyl- | HCID 541754 | — |
| Reactant | 7-(2-Chloroethoxy)-4-(1H-indazol-6-ylamino)-6-methoxyquinoline-3-carbonitrile | HCID 10294003 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | HCID 21704788 | HCID 21704788 | — |
Reaction Steps
Using an analogous procedure to that described in Example 157, 173.0 mg (0.44 mmol) of the 7-(2-chloro-ethoxy)-4-(1H-indazol-6-ylamino)-6-methoxy- quinoline-3-carbonitrile, 515.5 mg (4.4 mmol) of 2-([1,3]-dioxolan-2-ylmethyl-methylamine and 66.0 mg (0.44 mmol) of sodium iodide in 4 mL of DME was heated at 135° C. for 16 hr. The work up gave 136.1 mg (65.2%) of the product as a yellow solid, m.p. 185-187° C., mass (electrospray, m/e): M+H 475.1
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06288082B1 |
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| Source dataset | uspto-grants-2001_09 |
|---|
| ORD ID | ord-83db98b083544a258fcd0796aef0bf79 |
|---|
| Source note | uspto-grants-2001_09 |
|---|
