HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → 4-(1H-Indazol-6-ylamino)-6-methoxy-7-(2-morpholine-4-yl-ethoxy)quinoline-3-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 7-(2-Chloroethoxy)-4-(1H-indazol-6-ylamino)-6-methoxyquinoline-3-carbonitrile | HCID 10294003 | — |
| Product | 4-(1H-Indazol-6-ylamino)-6-methoxy-7-(2-morpholine-4-yl-ethoxy)quinoline-3-carbonitrile | HCID 10138391 | — |
Reaction Steps
The title compound was prepared by the procedure of Example 167 using 0.616 g of 7-(2-chloroethoxy)-4-(1H-indazol-6-ylamino)-6-methoxyquinoline-3-carbonitrile, 0.094 g of sodium iodide and 2.03 ml of morpholine to give after purification by chromatography (Silica Gel: ethyl acetate, ethyl acetate/methyl alcohol/triethyl amine 6:4:0.1) 0.196 g (28%) of the desired product. MP 133-135° C. :mass spectrum (electrospray m/e): M+H=445.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06288082B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-ed7c02b7952240a1a3a71d3b986489ab |
| Source note | uspto-grants-2001_09 |