4-Chloro-6,7-dimethoxy-quinoline-3-carbonitrile → HCID 10297734, compound

HRID 1595818Notes

Reaction equation

HRID 1595818 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][C:3]=1[C:16]#[N:17].[Cl:18][C:19]1[CH:20]=[C:21]([CH:23]=[CH:24][C:25]=1[S:26][C:27]1[N:28]([CH3:32])[CH:29]=[CH:30][N:31]=1)[NH2:22]>>[Cl:18][C:19]1[CH:20]=[C:21]([NH:22][C:2]2[C:11]3[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=3)[N:5]=[CH:4][C:3]=2[C:16]#[N:17])[CH:23]=[CH:24][C:25]=1[S:26][C:27]1[N:28]([CH3:32])[CH:29]=[CH:30][N:31]=1

Participants

3

Reactant 2

HCID 105866764-Chloro-6,7-dimethoxy-quinoline-3-carbonitrileHCID 114590883-chloro-4-(1-methyl-1H-imidazol-2-ylsulfanyl)phenylamine

Product 1

HCID 10297734HCID 10297734, compound

Procedure

In the manner of Example 141 reaction of 4-chloro-6,7-dimethoxy-3-quinolinecarbonitrile with 3-chloro-4-(1-methyl-2-imidazolylthio)aniline (WO-9615118) gave the title compound as a white solid, mp 302-307° C.

Sources & evidence

ORD record
ord-2a93b5e8f23c45289e0aa8ad7305490f
Source dataset
uspto-grants-2001_09
Patent number
US06288082B1

Reaction notes

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