Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1595821생성일: 2026년 10월 25일
Tetrahydrofuran → N-{4-[3-Chloro-4-(1-methyl-1H-imidazol-2-ylsulfanyl)-phenylamino]-3-cyano-quinolin-6-yl}-acrylamide
https://huagongshe.com/reaction/1595821
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Acryloyl chloride | HCID 13140 | — |
| 반응물 | 6-Amino-4-[3-chloro-4-(1-methyl-1H-imidazol-2-ylsulfanyl)-phenylamino]-quinoline-3-carbonitrile | HCID 10136058 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N-{4-[3-Chloro-4-(1-methyl-1H-imidazol-2-ylsulfanyl)-phenylamino]-3-cyano-quinolin-6-yl}-acrylamide | HCID 10298286 | — |
반응 단계
Dissolved most of 1.00 g (2.46 mmol) 6-amino-4-[3-chloro-4-(1-methyl-1H-imidazol-2-ylsulfanyl)-phenylamino]-quinoline-3-carbonitrile in 3.5 ml hot DMF, added 12 ml THF and chilled to 0° C. Added 377 μl triethyl amine and 225 μl (2.70 mmol) acryloyl chloride. Removed ice bath at 15 minutes and stripped solvent at 2 hours. Slurried residue in water, collected solids and air dried overnight. Boiled in ethyl acetate, collected solids and dried in vacuo, giving 670 mg of yellow-brown solid: mass spectrum (electrospray m/e): M+H=461.1, 462.2.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US06288082B1 |
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| 출처 데이터셋 | uspto-grants-2001_09 |
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| ORD ID | ord-12720dc9c1a542aeb74e6346eb69ab76 |
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| 출처 메모 | uspto-grants-2001_09 |
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