Pyridine → HCID 22462766, compound

HRID 1595922Notes

Reaction equation

HRID 1595922 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[CH:10]=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=3)[S:8][C:7]=2[CH:18]=1.C(O[C:23](=[O:25])[CH3:24])(=O)C.[N:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[C:10]([C:23]([C:24]3[CH:28]=[CH:29][C:30]([CH2:31][N:26]4[CH2:27][CH2:7][CH2:6][CH2:5]4)=[C:3]([CH3:4])[CH:18]=3)=[O:25])=[C:9]([C:11]3[CH:12]=[CH:13][C:14]([NH2:17])=[CH:15][CH:16]=3)[S:8][C:7]=2[CH:18]=1

Participants

4

Reactant 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 22462710HCID 22462710, compound

Product 1

HCID 22462766HCID 22462766, compound

Procedure

A solution of 15.0 g (58.7 mmol) of 6-methoxy-2-(4-aminophenyl)benzo[b]thiophene (Part B) in 350 mL of pyridine was treated with 17.0 mL (180 mmol) of acetic anhydride in a dropwise manner. After stirring for 2 h, the reaction was concentrated in vacuo to give 15.1 g (50.7 mmol; 87%) of the title compound as a yellow solid.

Workup

  1. concentrationthe reaction was concentrated in vacuo

Sources & evidence

ORD record
ord-55f682fe3440446b8c3e002914bae1a0
Source dataset
uspto-grants-2001_09
Patent number
US06288105B1

Reaction notes

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