Hydrochloric Acid → HCID 22462766, compound

Participants

Reaction Steps

A solution of 200 mg (0.40 mmol) of 3-methyl-4-[(1-pyrrolidinyl)methyl]phenyl 6-methoxy-2-(4-acetamidophenyl)benzo[b]thiophen-3-yl ketone (Part H) in 5 mL of MEOH was treated with 5 mL of conc. aq HCl. The reaction was heated to mild reflux for 1 hr and was concentrated in vacuo. The residue was taken up in 25 mL. of H2O, the solution basified to pH 12 with 5 N aq NaOH, and the mixture was extracted with EtOAc (2×25 mL). Trhe comrbined organic extracts were dried (K2CO3), filtered, and concentrated in vacuo to give 175 mg (0.38 mmol; 96%) of the title compound as a foam.

Provenance & Evidence