Oxalic Acid → 2-(4-Aminophenyl)-3-[4-(2-(1-pyrrolidinyl)ethoxy]benzyl]benzo[b]thiophene

Participants

Reaction Steps

By essentially following the conditions described in Preparation 2, Part D, the free base of the title compound was prepared as an oil from 2-(4-aminophenyl)benzo[b]thiophene-3-yl 4-[2-(1-pyrrolidinyl)ethoxy]phenyl ketone (Part C) in 85% yield following MPLC (SiO2; 30% then 40% THF with 5% TEA in hexanes). The product was converted to the dioxalate salt using two molar equivalents of oxalic acid and a similar procedure to that of Preparation 2-H, above.

Provenance & Evidence