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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1595928Generated: November 1, 2026

Cesium carbonate → 2-[4-(Cyanomethoxy)phenyl]-3-[4-[2-(1-pyrrolidinyl)ethoxy]benzyl]benzo[b]thiophene

https://huagongshe.com/reaction/1595928

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCesium carbonateHCID 10796—
ReactantBromoacetonitrileHCID 11534—
Reactant4-[3-[4-[2-(1-Pyrrolidinyl)ethoxy]benzyl]benzo[b]thiophen-2-yl]phenolHCID 22462655—
SolventDimethylformamideHCID 6228—
Product2-[4-(Cyanomethoxy)phenyl]-3-[4-[2-(1-pyrrolidinyl)ethoxy]benzyl]benzo[b]thiopheneHCID 22462772—

Reaction Steps

A suspension of 2-(4-hydroxyphenyl)-3-[4-[2-(1-pyrrolidinyl)ethoxy]benzyl]benzo[b]thiophene (102 mg) and cesium carbonate (386 mg) in DMF (3.0 mL) was treated with bromoacetonitrile (20 uL) while stirring at ambient temperature.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06288105B1
Source datasetuspto-grants-2001_09
ORD IDord-a97bb8c369c347a983531cda4bf80f32
Source noteuspto-grants-2001_09