Ammonium Hydroxide → 4-[1,1'-Biphenyl]-4-yl-6-chloro-1,3,5-triazin-2-amine

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-[1,1′-biphenyl]-4-yl-4,6-dichloro-1,3,5-triazine (Example 63A) (0.804 g, 2.67 mmol) in 40 mL ether and concentrated ammonium hydroxide (2 mL, 30 mmol) in tetrahydrofuran (30 mL) was stirred at 0° C. for 60 minutes and at ambient temperature for 20 minutes. The reaction was reduced in volume, diluted with water, and the precipitate was collected, rinsed with water and ether, and dried to provide the desired compound (0.090 g, 12%).

Provenance & Evidence