Sodium Hydroxide → HCID 20683881, compound

Participants

Reaction Steps

A solution of 307 mg of 17β-acetoxy-7α-{5-methylaminopentyl}-3-(tetrahydropyran-2-yloxy)-estra-1,3,5(10)-triene (Example 1h) in 6 ml of methanol is stirred with 1.5 ml of sodium hydroxide solution for 4 hours at room temperature. Then, it is diluted with ethyl acetate, washed with water, dried on sodium sulfate and concentrated by evaporation in a vacuum. 285 mg of 7α-{5-methylaminopentyl}-3-(tetrahydropyran-2-yloxy)-estra-1,3,5(10)-trien-17β-ol is obtained.

Provenance & Evidence