Water → HCID 9793894, compound

In a 300 mL beaker was placed 5.78 g (57 mmol) of 3-morpholinone (I), 50% (w/w)sodium hydroxide (5.02 g, 63 mmol), 100 mL of water and a magnetic stir bar. The resulting solution was heated for 30 min at a gentle boil then cooled to room temperature. While the solution was stirring at room temperature, the glycolonitrile (40 percent aqueous, 8.13 g, 57 mmol) was added dropwise. The solution was stirred at room temperature for 1 h. at which time a 13C NMR indicated that the reaction was complete. 13C NMR (D2O): δ 50.3, 53.4, 119.4, 179.7, 180.9 ppm.

1. temperatureThe resulting solution was heated for 30 min at a gentle boil
2. stirringThe solution was stirred at room temperature for 1 h. at which time a 13C NMR

ORD record

ord-3157c621def14c0aa4d2a50314ae0ac2

Source dataset

uspto-grants-2001_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06288263B1