Phosphoric Acid → HCID 53695575, compound

Participants

Reaction Steps

To a solution of Example 3B (4.66 g, 16.9 mmol) and triethylamine (2.70 mL, 19.4 mmol) in THF (25 mL) at −20° C. was added methyl chloroformate (1.60 mL, 10.3 mmol), and the resulting solution was stirred for 15 minutes. This solution was then added to sodium borohydride (1.92 g, 50.6 mmol) in water (10 mL) at 0° C., stirred at room temperature for 2 hours, acidified with 0.5 M H3PO4, and extracted with ethyl acetate. The ethyl acetate was washed with water, brine, dried (MgSO4), filtered, and concentrated to provide 2.10 g (47%) of the desired compound.

Provenance & Evidence