HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromonaphthalene-2-carbaldehyde → (1-Bromonaphthalen-2-yl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromonaphthalene-2-carbaldehyde | HCID 76909 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (1-Bromonaphthalen-2-yl)methanol | HCID 13113200 | 92.3% |
Reaction Steps
A solution of 1-bromo-2-naphthaldehyde (2.12 g, 8.91 mmol) in MeOH under N2 at 0° C. was treated with NaBH4 (0.51 g, 13.4 mmol), stirred for 15 minutes, quenched with acetone, and concentrated. Purification on silica gel with 5% ethyl acetate/CH2Cl2 provided 1.95 g (92%) of the desired compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06288261B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-6e3aac090eda42cfb50f990f50991962 |
| Source note | uspto-grants-2001_09 |