Trifluoroacetic acid → HCID 11767389, compound

Participants

Reaction Conditions

Reaction Steps

A solution of Example 9F (1.19 g, 1.72 mmol) in CH2Cl2 (35 mL) under N2 at −20° C. was treated with trifluoroacetic acid (13.3 mL, 0.172 mol) and allowed to stir at 0° C. 2 for 1 hour and then quenched with 2.6 M Na2CO3 (50 mL). The reaction mixture was reacidified to pH 3 with 1 M aq HCl, extracted with ethyl acetate. The combined ogranic layers were washed with brine, dried (Na2SO4), filtered, and concentrated (chasing with anhydrous toluene) to provide 1.096 g (100%) of the desired compound white powder.

Provenance & Evidence