HCID 21705598, compound → HCID 10913048, compound

Participants

Reaction Steps

A solution of Example 11B (1.4 g, 5.18 mmol) in acetone (20 mL) was treated with Jones reagent (CrO3/H2SO4) until the orange color persisted, quenched with isopropyl alcohol, partitioned between ethyl acetate and water. The organic layer was washed with water, dried (Na2SO4), filtered, concentrated, and purified on silica gel with a gradient of 30% ethyl acetate/hexanes to 10% MeOH/dichloromethane to provide 1.27 g (86%) of the desired compound as an yellow oil.

Provenance & Evidence