Piperidine → HCID 10971939, compound

Participants

Reaction Steps

A solution of Example 11F (200 mg, 0.431 mmol) in dichloromethane (5 mL) at room temperature was treated with tetrakis(triphenylphosphine)palladium (43 mg, 0.0375 mmol), triphenylphosphine (19.6 mg, 0.075 mmol), piperidine (0.0447 mL, 0.452 mmol), and allowed to stir at room temperature for 30 minutes. The reaction mixture was diluted with 0.5 N HCl, and extracted with dichloromethane. The organic layer was dried (Na2SO4), filtered, concentrated, and purified on silica gel with 10% methanol/CH2Cl2 to provide 197 mg (100%) of the desired compound as an white solid.

Provenance & Evidence