反应详情

Concentrated aqueous ammonia (15 ml) was added to a solution of 2-fluoro-5-methoxycarbonyloxyaniline (400 mg, 2.16 mmol) in methanol (10 ml). The mixture was stirred for 2 hours and most of the solvent was removed by evaporation. The resulting suspension was diluted with water, acidified to pH7 and extracted with ethyl acetate. The organic extracts were washed with water, dried (MgSO4) and solvent removed by evaporation to give 2-fluoro-5-hydroxyaniline (200 mg, 73%).

1. customwas removed by evaporation
2. additionThe resulting suspension was diluted with water
3. extractionextracted with ethyl acetate
4. washThe organic extracts were washed with water
5. dry with materialdried (MgSO4) and solvent
6. customremoved by evaporation