7-(Benzyloxy)-4-chloro-6-methoxyquinazoline → 4-(3-Acetoxy-4-methylanilino)-7-benzyloxy-6-methoxyquinazoline

Participants

Reaction Steps

A mixture of 7-benzyloxy4-chloro-6-methoxyquinazoline (2.18 g, 7.25 mmol), (prepared as described for the starting material in Example 4), 3-acetoxy-4-methylaniline (1.32 g, 8 mmol) and isopropanol (50 ml) was stirred and heated at reflux for 1 hour. The mixture was cooled to ambient temperature. The precipitate was collected by filtration, washed with isopropanol and ether to give 4-(3-acetoxy-4-methylanilino)-7-benzyloxy-6-methoxyquinazoline.

Provenance & Evidence