5-Amino-2-methylphenol → HCID 21701565, compound

Participants

Reaction Steps

A mixture of 4-chloro-6,7-dimethoxyquinazoline hydrochloride (130 mg, 0.5 mmol), (prepared as described for the starting material in Example 2), and 3-hydroxy-4-methylaniline (62 mg, 0.5 mmol) in isopropanol (7 ml) was heated at reflux for 2 hours. The mixture was allowed to cool to ambient temperature, the precipitated solid was collected by filtration, washed with isopropanol and ether and dried to give 6,7-dimethoxy-4-(3-hydroxy-4-methylanilino)quinazoline hydrochloride (98 mg, 56%) as an off-white solid.

Provenance & Evidence