HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Hydroxybenzotriazole → HCID 16727971, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 2-(Isoquinolin-5-yloxy)acetic acid | HCID 12902790 | — |
| Reactant | HCID 20686737 | HCID 20686737 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 16727971 | HCID 16727971 | 77.2% |
Reaction Steps
5-isoquinolinyloxyacetic acid (64 mg), HOBt (43 mg), and EDC.HCl (60 mg) were added to H-Val-Apns-Dmt-NHBzl(2-Me) (162 mg) obtained in the step 2 and the mixture was stirred overnight. After the addition of ethyl acetate, the reaction mixture was washed with 3% NaHCO3 and 5% NaCl and dried over MgSO4. After filtration and concentration, the residue was reprecipitated from ethyl acetate/n-hexane to obtain the title compound (168 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06291432B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-6aacf038040140568c07055b5f8591d5 |
| Source note | uspto-grants-2001_09 |