HCID 54238483, compound → HCID 136401073, compound

Participants

Reaction Steps

To a solution of (3RS)-1-[(3-azabicyclo[3.2.2]non-3-yl)carbonylmethyl]-3-benzyloxycarbonylamino-5-cyclohexylmethyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one (0.396 g) in methanol (15 ml) was added Pearlman's catalyst (0.111 g). The mixture was stirred under H2 atmosphere over night. The catalyst was filtered off by suction filtration on Celite®. The filtrate was concentrated in vacuo to give (3RS)-3-amino-1-[(3-azalicyclo[3.2.2]non-3-yl)carbonylmethyl]-5-cyclohexylmethyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one (0.298 g), which was used in a following reaction step without further purification.

Provenance & Evidence