Sodium Iodide → HCID 21701385, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (3RS)-3-acetoxy-5-(2-fluorophenyl)-9-isopropyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one (2.73 g), sodium iodide (11.5 g) and phthalimide potassium salt (2.14 g) in N,N-dimethylformamide (18 ml) was stirred at 90° C. for 1.3 hours. The hot reaction mixture was poured into an ice with stirring to afford precipitates, which were collected by filtration, washed with water and air dried at room temperature to afford (3RS)-3-phthalimido-5-(2-fluorophenyl)-9-isopropyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one (3.08 g, 90.6%) as a crystalline powder.

Provenance & Evidence