Hydrogen Bromide → HCID 21701348, compound

Participants

Reaction Steps

A mixture of (3RS)-3-benzyloxycarbonylamino-2,3-dihydro-5-(2-fluorophenyl)-9-methyl-1-(2-nitrophenacyl)-1H-1,4-benzodiazepin-2-one (300 mg)and 30% hydrobromic acid in acetic acid (3 ml) was stirred at room temperature for 4.5 hours. Water and ice were added to the reaction mixture to afford powder, which was collected by filtration, and washed with water to give (3RS)-3-amino-2,3-dihydro-5-(2-fluorophenyl)-9-methyl-1-(2-nitrophenacyl)-1H-1,4-benzodiazepin-2-one hydrobromide (227 mg, 81.8%).

Provenance & Evidence