反应详情

A mixture of 2-bromo-3′-ethoxyacetophenone (2.4 g, 10 m mol), phenol (1.0 g, 10.6 m mol), potassium carbonate (2.0 g, 14.5 m mol) and acetone (30 ml) was heated under reflux for 6 hours. After insoluble matter was filtered off, the solvent was distilled off under reduced pressure. The residue was dissolved in chloroform (40 ml), washed with water (2×20 ml), and dried. Thereafter, the solvent was distilled off under reduced pressure. The resulting residue was subjected to chromatography on silica gel (50 g) using chloroform. Thus, the desired compound (1.94 g, 75%) was obtained as an oily material.

1. temperaturewas heated
2. temperatureunder reflux for 6 hours
3. filtrationAfter insoluble matter was filtered off
4. distillationthe solvent was distilled off under reduced pressure
5. dissolutionThe residue was dissolved in chloroform (40 ml)
6. washwashed with water (2×20 ml)
7. customdried
8. distillationThereafter, the solvent was distilled off under reduced pressure