Phenol → 3'-Ethoxy-2-phenoxyacetophenone

HRID 1596406ノート

反応式

HRID 1596406 の反応式
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][CH2:12][CH3:13])[CH:6]=1)=[O:4].[C:14]1([OH:20])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:12]([O:11][C:7]1[CH:6]=[C:5]([C:3](=[O:4])[CH2:2][O:20][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:10]=[CH:9][CH:8]=1)[CH3:13]

参加物

5

反応物 3

HCID 996PhenolHCID 11430Potassium CarbonateHCID 226410062-Bromo-1-(3-ethoxyphenyl)ethanone

生成物 1

HCID 217020453'-Ethoxy-2-phenoxyacetophenone収率 76.7%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 2-bromo-3′-ethoxyacetophenone (2.4 g, 10 m mol), phenol (1.0 g, 10.6 m mol), potassium carbonate (2.0 g, 14.5 m mol) and acetone (30 ml) was heated under reflux for 6 hours. After insoluble matter was filtered off, the solvent was distilled off under reduced pressure. The residue was dissolved in chloroform (40 ml), washed with water (2×20 ml), and dried. Thereafter, the solvent was distilled off under reduced pressure. The resulting residue was subjected to chromatography on silica gel (50 g) using chloroform. Thus, the desired compound (1.94 g, 75%) was obtained as an oily material.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 6 hours
  3. filtrationAfter insoluble matter was filtered off
  4. distillationthe solvent was distilled off under reduced pressure
  5. dissolutionThe residue was dissolved in chloroform (40 ml)
  6. washwashed with water (2×20 ml)
  7. customdried
  8. distillationThereafter, the solvent was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-e3579f899cbe491584c43ff86737e0e2
出典データセット
uspto-grants-2001_09
特許番号
US06291485B1

反応ノート

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